相互作用
Amobarbital + Guanfacine
重症度: 中等度
Amobarbital and Guanfacine: moderate interaction.
最終更新日
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概要
Amobarbital can substantially lower guanfacine concentrations through CYP3A4 induction, reducing blood pressure or ADHD effect. Additive sedation may also occur.
この相互作用をわかりやすく説明すると
Amobarbital and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
なぜ起こるのか
CYP3A4 induction increases guanfacine metabolism.
対処法
Monitor blood pressure and clinical response and consider guanfacine dose increase per labeling; reduce the dose again if the inducer is stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmobarbitalとGuanfacineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amobarbitalのその他の相互作用
Guanfacineのその他の相互作用
よくある質問
Can I take Amobarbital with Guanfacine?
MediHelp rates the interaction as moderate. Amobarbital and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can substantially lower guanfacine concentrations through CYP3A4 induction, reducing blood pressure or ADHD effect. Additive sedation may also occur.
How serious is the interaction between Amobarbital and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response and consider guanfacine dose increase per labeling; reduce the dose again if the inducer is stopped.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
