相互作用
Cocaine + Desipramine
重症度: 重大
Cocaine and Desipramine: major interaction.
最終更新日
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概要
Tricyclics block catecholamine reuptake, and cocaine does the same, so the sympathomimetic effects may be potentiated. With topical cocaine this is mainly relevant when large doses are absorbed, with risk of hypertension and arrhythmia.
この相互作用をわかりやすく説明すると
Cocaine and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
なぜ起こるのか
Additive inhibition of norepinephrine reuptake, increasing adrenergic stimulation and arrhythmia risk.
対処法
Avoid cocaine in patients taking desipramine, including topical anesthetic use, where an alternative anesthetic can be chosen. If unavoidable, use the minimum dose and monitor blood pressure and ECG.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CocaineとDesipramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Desipramineのその他の相互作用
Cocaineのその他の相互作用
よくある質問
Can I take Cocaine with Desipramine?
MediHelp rates the interaction as major. Cocaine and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics block catecholamine reuptake, and cocaine does the same, so the sympathomimetic effects may be potentiated. With topical cocaine this is mainly relevant when large doses are absorbed, with risk of hypertension and arrhythmia.
How serious is the interaction between Cocaine and Desipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine in patients taking desipramine, including topical anesthetic use, where an alternative anesthetic can be chosen. If unavoidable, use the minimum dose and monitor blood pressure and ECG.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
