相互作用
Colchicine + Neratinib
重症度: 重大
Colchicine and Neratinib: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Neratinib inhibits P-glycoprotein and may raise colchicine concentrations. The resulting higher exposure increases colchicine toxicity risk, especially in renal or hepatic impairment.
この相互作用をわかりやすく説明すると
Colchicine and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Neratinib belongs to Oncology.
なぜ起こるのか
Neratinib inhibits P-gp efflux of colchicine.
対処法
Avoid in renal or hepatic impairment. Otherwise consider reducing the colchicine dose and monitor for toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ColchicineとNeratinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Colchicineのその他の相互作用
Neratinibのその他の相互作用
よくある質問
Can I take Colchicine with Neratinib?
MediHelp rates the interaction as major. Colchicine and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Neratinib inhibits P-glycoprotein and may raise colchicine concentrations. The resulting higher exposure increases colchicine toxicity risk, especially in renal or hepatic impairment.
How serious is the interaction between Colchicine and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in renal or hepatic impairment. Otherwise consider reducing the colchicine dose and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
