相互作用
Cyclosporine + Fluvastatin
重症度: 重大
Cyclosporine and Fluvastatin: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Cyclosporine increases fluvastatin exposure and the risk of myopathy and rhabdomyolysis.
この相互作用をわかりやすく説明すると
Cyclosporine and Fluvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Cyclosporine inhibits OATP1B1 and CYP2C9, reducing fluvastatin clearance.
対処法
Limit fluvastatin to 20 mg twice daily with cyclosporine. Monitor for muscle symptoms and check CK if they occur.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporineとFluvastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Fluvastatinのその他の相互作用
よくある質問
Can I take Cyclosporine with Fluvastatin?
MediHelp rates the interaction as major. Cyclosporine and Fluvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine increases fluvastatin exposure and the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Cyclosporine and Fluvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit fluvastatin to 20 mg twice daily with cyclosporine. Monitor for muscle symptoms and check CK if they occur.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
