相互作用
Apalutamide + Fluvastatin
重症度: 中等度
Apalutamide and Fluvastatin: moderate interaction.
最終更新日
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概要
Apalutamide is a weak CYP2C9 inducer and induces other clearance pathways. It may lower fluvastatin exposure, which is mainly cleared by CYP2C9, and so weaken its lipid-lowering effect.
この相互作用をわかりやすく説明すると
Apalutamide and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Fluvastatin belongs to Cardiovascular.
なぜ起こるのか
Apalutamide induces CYP2C9 and weakly induces transporters, increasing fluvastatin clearance.
対処法
Monitor the lipid profile after starting or stopping apalutamide. Increase the fluvastatin dose or switch statin if efficacy is lost.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとFluvastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluvastatinのその他の相互作用
Apalutamideのその他の相互作用
よくある質問
Can I take Apalutamide with Fluvastatin?
MediHelp rates the interaction as moderate. Apalutamide and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a weak CYP2C9 inducer and induces other clearance pathways. It may lower fluvastatin exposure, which is mainly cleared by CYP2C9, and so weaken its lipid-lowering effect.
How serious is the interaction between Apalutamide and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile after starting or stopping apalutamide. Increase the fluvastatin dose or switch statin if efficacy is lost.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
