相互作用
Danazol + Flutamide
重症度: 中等度
Danazol and Flutamide: moderate interaction.
最終更新日
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概要
Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
この相互作用をわかりやすく説明すると
Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Danazol inhibits CYP3A4 and has pharmacodynamic androgenic activity opposing flutamide.
対処法
Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DanazolとFlutamideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Flutamideのその他の相互作用
よくある質問
Can I take Danazol with Flutamide?
MediHelp rates the interaction as moderate. Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
How serious is the interaction between Danazol and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
