相互作用
Flutamide + Pretomanid
重症度: 重大
Flutamide and Pretomanid: major interaction.
最終更新日
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概要
Pretomanid-containing regimens are associated with hepatotoxicity, and flutamide also carries a boxed warning for liver injury. Combined use may increase the chance of serious liver damage.
この相互作用をわかりやすく説明すると
Flutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
なぜ起こるのか
Additive hepatotoxicity.
対処法
Avoid flutamide during pretomanid therapy and use another antiandrogen if needed. If unavoidable, monitor liver enzymes frequently.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FlutamideとPretomanidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Flutamideのその他の相互作用
Pretomanidのその他の相互作用
よくある質問
Can I take Flutamide with Pretomanid?
MediHelp rates the interaction as major. Flutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and flutamide also carries a boxed warning for liver injury. Combined use may increase the chance of serious liver damage.
How serious is the interaction between Flutamide and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid flutamide during pretomanid therapy and use another antiandrogen if needed. If unavoidable, monitor liver enzymes frequently.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
