相互作用
Flutamide + Pexidartinib
重症度: 重大
Flutamide and Pexidartinib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
この相互作用をわかりやすく説明すると
Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Pexidartinib belongs to Oncology.
なぜ起こるのか
Additive hepatotoxicity from two hepatotoxic drugs.
対処法
Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FlutamideとPexidartinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Flutamideのその他の相互作用
Pexidartinibのその他の相互作用
よくある質問
Can I take Flutamide with Pexidartinib?
MediHelp rates the interaction as major. Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
How serious is the interaction between Flutamide and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pretomanid. The full list is on the Flutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
