相互作用
Dapagliflozin + Glimepiride
重症度: 中等度
Dapagliflozin and Glimepiride: moderate interaction.
最終更新日
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概要
Dapagliflozin has a low intrinsic hypoglycemia risk, but together with glimepiride the risk increases. Episodes can be prolonged given the sulfonylurea's duration of action.
この相互作用をわかりやすく説明すると
Dapagliflozin and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glimepiride belongs to Endocrine.
なぜ起こるのか
Additive pharmacodynamic glucose lowering through urinary glucose loss and insulin secretion.
対処法
Consider a lower glimepiride dose when dapagliflozin is started. Monitor blood glucose closely.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DapagliflozinとGlimepirideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glimepirideのその他の相互作用
Dapagliflozinのその他の相互作用
よくある質問
Can I take Dapagliflozin with Glimepiride?
MediHelp rates the interaction as moderate. Dapagliflozin and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin has a low intrinsic hypoglycemia risk, but together with glimepiride the risk increases. Episodes can be prolonged given the sulfonylurea's duration of action.
How serious is the interaction between Dapagliflozin and Glimepiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower glimepiride dose when dapagliflozin is started. Monitor blood glucose closely.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
