相互作用
Dapagliflozin + Glimepiride-pioglitazone
重症度: 中等度
Dapagliflozin and Glimepiride-pioglitazone: moderate interaction.
最終更新日
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概要
Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
この相互作用をわかりやすく説明すると
Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
なぜ起こるのか
Additive glucose-lowering through insulin-independent urinary glucose excretion plus sulfonylurea-driven insulin secretion.
対処法
Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DapagliflozinとGlimepiride-pioglitazoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glimepiride-pioglitazoneのその他の相互作用
Dapagliflozinのその他の相互作用
よくある質問
Can I take Dapagliflozin with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
How serious is the interaction between Dapagliflozin and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
