相互作用
Chlorpropamide + Dapagliflozin
重症度: 中等度
Chlorpropamide and Dapagliflozin: moderate interaction.
最終更新日
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概要
Dapagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide's long duration of action may make hypoglycemia prolonged.
この相互作用をわかりやすく説明すると
Chlorpropamide and Dapagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Dapagliflozin belongs to Endocrine.
なぜ起こるのか
Additive glucose lowering from sulfonylurea-stimulated insulin secretion and SGLT2-mediated glucosuria.
対処法
Consider reducing the chlorpropamide dose when starting dapagliflozin and monitor blood glucose closely, especially in older or renally impaired patients.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorpropamideとDapagliflozinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlorpropamideのその他の相互作用
Dapagliflozinのその他の相互作用
よくある質問
Can I take Chlorpropamide with Dapagliflozin?
MediHelp rates the interaction as moderate. Chlorpropamide and Dapagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide's long duration of action may make hypoglycemia prolonged.
How serious is the interaction between Chlorpropamide and Dapagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when starting dapagliflozin and monitor blood glucose closely, especially in older or renally impaired patients.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
