相互作用
Deferasirox + Prasugrel
重症度: 重大
Deferasirox and Prasugrel: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Deferasirox can cause GI ulceration and hemorrhage, and prasugrel potently inhibits platelet aggregation. Together they markedly raise the risk of serious GI bleeding.
この相互作用をわかりやすく説明すると
Deferasirox and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Prasugrel belongs to Cardiovascular.
なぜ起こるのか
Additive bleeding risk from deferasirox mucosal injury and irreversible P2Y12 platelet inhibition.
対処法
Monitor for GI bleeding and hemoglobin, consider gastroprotection with a proton pump inhibitor, and reassess the need for both drugs in patients with bleeding risk.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DeferasiroxとPrasugrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Deferasiroxのその他の相互作用
Prasugrelのその他の相互作用
よくある質問
Can I take Deferasirox with Prasugrel?
MediHelp rates the interaction as major. Deferasirox and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can cause GI ulceration and hemorrhage, and prasugrel potently inhibits platelet aggregation. Together they markedly raise the risk of serious GI bleeding.
How serious is the interaction between Deferasirox and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and hemoglobin, consider gastroprotection with a proton pump inhibitor, and reassess the need for both drugs in patients with bleeding risk.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
