相互作用
Deferiprone + Topotecan
重症度: 重大
Deferiprone and Topotecan: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Topotecan causes dose-limiting bone marrow suppression, especially neutropenia, and deferiprone can cause agranulocytosis. Combined use may produce severe neutropenia and serious infection.
この相互作用をわかりやすく説明すると
Deferiprone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Topotecan belongs to Oncology.
なぜ起こるのか
Additive myelosuppressive toxicity (pharmacodynamic).
対処法
Avoid if possible; otherwise monitor absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DeferiproneとTopotecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Topotecanのその他の相互作用
Deferiproneのその他の相互作用
よくある質問
Can I take Deferiprone with Topotecan?
MediHelp rates the interaction as major. Deferiprone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Topotecan causes dose-limiting bone marrow suppression, especially neutropenia, and deferiprone can cause agranulocytosis. Combined use may produce severe neutropenia and serious infection.
How serious is the interaction between Deferiprone and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor absolute neutrophil count more frequently and interrupt deferiprone if neutropenia occurs.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
