相互作用
Deflazacort + Etravirine
重症度: 重大
Deflazacort and Etravirine: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Etravirine is a CYP3A4 inducer and may lower exposure to deflazacort's active metabolite. Reduced corticosteroid efficacy may result.
この相互作用をわかりやすく説明すると
Deflazacort and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deflazacort belongs to Miscellaneous; Etravirine belongs to Anti Virals.
なぜ起こるのか
Etravirine induces CYP3A4, increasing clearance of deflazacort's active metabolite.
対処法
Avoid concomitant use where possible. If it cannot be avoided, monitor for loss of efficacy and consider an alternative corticosteroid or dose adjustment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DeflazacortとEtravirineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Deflazacortのその他の相互作用
- Adenovirus types 4 and 7 live + Deflazacort 併用禁忌
- Bcg vaccine live + Deflazacort 併用禁忌
- Deflazacort + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Deflazacort + Measles mumps and rubella vaccine 併用禁忌
- Deflazacort + Measles mumps and rubella vaccine live 併用禁忌
- Deflazacort + Measles mumps rubella and varicella vaccine live 併用禁忌
Etravirineのその他の相互作用
よくある質問
Can I take Deflazacort with Etravirine?
MediHelp rates the interaction as major. Deflazacort and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etravirine is a CYP3A4 inducer and may lower exposure to deflazacort's active metabolite. Reduced corticosteroid efficacy may result.
How serious is the interaction between Deflazacort and Etravirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible. If it cannot be avoided, monitor for loss of efficacy and consider an alternative corticosteroid or dose adjustment.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
