相互作用
Efavirenz + Etravirine
重症度: 併用禁忌
Efavirenz and Etravirine: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Efavirenz substantially lowers etravirine concentrations, which may cause loss of virologic control. Combining two NNRTIs offers no benefit and is not recommended.
この相互作用をわかりやすく説明すると
Efavirenz and Etravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Etravirine belongs to Anti Virals.
なぜ起こるのか
Efavirenz induces CYP3A4 and CYP2C19, increasing etravirine metabolism.
対処法
Do not coadminister. Use a single NNRTI within a regimen suited to the resistance profile.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EfavirenzとEtravirineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Efavirenzのその他の相互作用
Etravirineのその他の相互作用
よくある質問
Can I take Efavirenz with Etravirine?
MediHelp rates the interaction as contraindicated. Efavirenz and Etravirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz substantially lowers etravirine concentrations, which may cause loss of virologic control. Combining two NNRTIs offers no benefit and is not recommended.
How serious is the interaction between Efavirenz and Etravirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use a single NNRTI within a regimen suited to the resistance profile.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
