相互作用
Dobutamine + Isocarboxazid
重症度: 重大
Dobutamine and Isocarboxazid: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
この相互作用をわかりやすく説明すると
Dobutamine and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
なぜ起こるのか
Reduced catecholamine degradation (MAO inhibition) with sympathomimetic stimulation
対処法
Avoid where possible; if dobutamine is required in a patient taking isocarboxazid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DobutamineとIsocarboxazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Dobutamineのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Dobutamine with Isocarboxazid?
MediHelp rates the interaction as major. Dobutamine and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
How serious is the interaction between Dobutamine and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if dobutamine is required in a patient taking isocarboxazid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
