相互作用
Domperidone + Polyethylene Glycol 3350
重症度: 中等度
Domperidone and Polyethylene Glycol 3350: moderate interaction.
最終更新日
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概要
There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
この相互作用をわかりやすく説明すると
Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Pharmacodynamic and indirect: laxative-induced fluid and electrolyte loss lowers potassium and magnesium, which potentiates the QT-prolonging effect of domperidone. No pharmacokinetic interaction is expected.
対処法
Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DomperidoneとPolyethylene Glycol 3350の臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Domperidone Summary of Product Characteristics - Special warnings and precautions (cardiovascular effects, electrolyte disturbances) — EMA SmPC
- Domperidone: risks of cardiac side effects - restricted indications, new contraindications, and reduced dose and duration of use — MHRA Drug Safety Update
Domperidoneのその他の相互作用
よくある質問
Can I take Domperidone with Polyethylene Glycol 3350?
MediHelp rates the interaction as moderate. Domperidone and Polyethylene Glycol 3350 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. There is no direct interaction, but excessive polyethylene glycol use that causes persistent diarrhea can lead to hypokalemia and hypomagnesemia. Electrolyte disturbance is a recognised risk factor for QT prolongation and torsades de pointes with domperidone. The concern is conditional and relevant mainly to high-risk patients.
How serious is the interaction between Domperidone and Polyethylene Glycol 3350?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use PEG at the lowest effective dose and stop or reduce it if diarrhea develops. Check and correct potassium and magnesium in patients with persistent diarrhea who take domperidone.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
