相互作用
Azithromycin + Domperidone
重症度: 併用禁忌
Azithromycin and Domperidone: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Both drugs prolong the QT interval, and combined use increases the risk of torsades de pointes and sudden cardiac death. European labeling contraindicates domperidone with QT-prolonging drugs. Patients with cardiac disease, electrolyte disturbance or other QT risk factors are at greatest risk.
この相互作用をわかりやすく説明すると
Azithromycin and Domperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azithromycin belongs to Anti Bacterial; Domperidone belongs to Gastrointestinal Tract.
なぜ起こるのか
Pharmacodynamic: additive QT prolongation through hERG potassium channel blockade. Azithromycin is only a weak CYP3A4 inhibitor, so any pharmacokinetic contribution is small.
対処法
Do not co-administer. Choose an antibiotic without QT effect, such as a beta-lactam where appropriate, or an antiemetic or prokinetic without QT risk.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、AzithromycinとDomperidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Domperidone Summary of Product Characteristics - Contraindications and Interactions — EMA SmPC
- Zithromax (azithromycin) Prescribing Information - QT Prolongation — FDA Label
Azithromycinのその他の相互作用
Domperidoneのその他の相互作用
よくある質問
Can I take Azithromycin with Domperidone?
MediHelp rates the interaction as contraindicated. Azithromycin and Domperidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combined use increases the risk of torsades de pointes and sudden cardiac death. European labeling contraindicates domperidone with QT-prolonging drugs. Patients with cardiac disease, electrolyte disturbance or other QT risk factors are at greatest risk.
How serious is the interaction between Azithromycin and Domperidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antibiotic without QT effect, such as a beta-lactam where appropriate, or an antiemetic or prokinetic without QT risk.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Dronedarone, Pimozide. The full list is on the Azithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
