相互作用
Artemether / lumefantrine + Dronedarone
重症度: 併用禁忌
Artemether / lumefantrine and Dronedarone: contraindicated interaction.
最終更新日
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概要
Both components prolong the QT interval, and the combination with dronedarone increases torsades risk. Artemether is also a CYP3A4 substrate with possible effects on dronedarone exposure, though QT additivity is the main concern.
この相互作用をわかりやすく説明すると
Artemether / lumefantrine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive QT prolongation, with possible CYP3A4-mediated pharmacokinetic effects.
対処法
Avoid the combination; use an antimalarial without QT liability or withhold dronedarone if treatment is essential, with ECG monitoring.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Artemether / lumefantrineとDronedaroneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dronedaroneのその他の相互作用
よくある質問
Can I take Artemether / lumefantrine with Dronedarone?
MediHelp rates the interaction as contraindicated. Artemether / lumefantrine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both components prolong the QT interval, and the combination with dronedarone increases torsades risk. Artemether is also a CYP3A4 substrate with possible effects on dronedarone exposure, though QT additivity is the main concern.
How serious is the interaction between Artemether / lumefantrine and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antimalarial without QT liability or withhold dronedarone if treatment is essential, with ECG monitoring.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
