相互作用
Duloxetine + Rasagiline
重症度: 併用禁忌
Duloxetine and Rasagiline: contraindicated interaction.
最終更新日
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概要
Combining an MAO inhibitor with an SNRI can cause serotonin syndrome and severe CNS toxicity with hyperthermia. Duloxetine labeling contraindicates use with MAO inhibitors, and rasagiline labeling advises against combining with antidepressants.
この相互作用をわかりやすく説明すると
Duloxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Duloxetine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
なぜ起こるのか
MAO-B inhibition (with reduced selectivity at higher doses) combined with serotonin and norepinephrine reuptake inhibition causes excess synaptic monoamines.
対処法
Do not coadminister. Allow at least 14 days after stopping rasagiline before starting duloxetine, and at least 5 days after stopping duloxetine before starting rasagiline.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、DuloxetineとRasagilineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Duloxetineのその他の相互作用
Rasagilineのその他の相互作用
よくある質問
Can I take Duloxetine with Rasagiline?
MediHelp rates the interaction as contraindicated. Duloxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with an SNRI can cause serotonin syndrome and severe CNS toxicity with hyperthermia. Duloxetine labeling contraindicates use with MAO inhibitors, and rasagiline labeling advises against combining with antidepressants.
How serious is the interaction between Duloxetine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days after stopping rasagiline before starting duloxetine, and at least 5 days after stopping duloxetine before starting rasagiline.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
