相互作用
Dronedarone + Fosphenytoin
重症度: 併用禁忌
Dronedarone and Fosphenytoin: contraindicated interaction.
最終更新日
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概要
Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer, which can markedly lower dronedarone concentrations. This may lead to loss of antiarrhythmic effect.
この相互作用をわかりやすく説明すると
Dronedarone and Fosphenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Fosphenytoin belongs to Central Nervous System.
なぜ起こるのか
Induction of CYP3A4 increases dronedarone metabolism.
対処法
Avoid the combination; use an alternative anticonvulsant or antiarrhythmic.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DronedaroneとFosphenytoinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dronedaroneのその他の相互作用
Fosphenytoinのその他の相互作用
よくある質問
Can I take Dronedarone with Fosphenytoin?
MediHelp rates the interaction as contraindicated. Dronedarone and Fosphenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer, which can markedly lower dronedarone concentrations. This may lead to loss of antiarrhythmic effect.
How serious is the interaction between Dronedarone and Fosphenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative anticonvulsant or antiarrhythmic.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
