相互作用
Glycerol phenylbutyrate + Valproic acid
重症度: 重大
Glycerol phenylbutyrate and Valproic acid: major interaction.
最終更新日
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概要
Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, whereas valproate can cause hyperammonemia, sometimes severe, by interfering with the urea cycle. Valproate can therefore counteract the treatment and may precipitate hyperammonemic crises in these patients.
この相互作用をわかりやすく説明すると
Glycerol phenylbutyrate and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glycerol phenylbutyrate belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
なぜ起こるのか
Valproate inhibits urea cycle function (carbamoyl phosphate synthetase I via carnitine depletion and metabolite effects), opposing ammonia-lowering therapy.
対処法
Avoid valproate in urea cycle disorders when possible and choose another anticonvulsant. If it must be used, monitor plasma ammonia closely and adjust the nitrogen-scavenger therapy.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、Glycerol phenylbutyrateとValproic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Valproic acidのその他の相互作用
Glycerol phenylbutyrateのその他の相互作用
よくある質問
Can I take Glycerol phenylbutyrate with Valproic acid?
MediHelp rates the interaction as major. Glycerol phenylbutyrate and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, whereas valproate can cause hyperammonemia, sometimes severe, by interfering with the urea cycle. Valproate can therefore counteract the treatment and may precipitate hyperammonemic crises in these patients.
How serious is the interaction between Glycerol phenylbutyrate and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid valproate in urea cycle disorders when possible and choose another anticonvulsant. If it must be used, monitor plasma ammonia closely and adjust the nitrogen-scavenger therapy.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
