相互作用
Ibutilide + Moxifloxacin
重症度: 併用禁忌
Ibutilide and Moxifloxacin: contraindicated interaction.
最終更新日
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概要
Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Adding moxifloxacin further increases QT prolongation and arrhythmia risk.
この相互作用をわかりやすく説明すると
Ibutilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
なぜ起こるのか
Additive potassium channel blockade leading to delayed ventricular repolarization.
対処法
Do not coadminister; use an alternative antibacterial while ibutilide is being used. Correct hypokalemia and hypomagnesemia and monitor ECG if exposure has occurred.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IbutilideとMoxifloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Moxifloxacinのその他の相互作用
Ibutilideのその他の相互作用
よくある質問
Can I take Ibutilide with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Ibutilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Adding moxifloxacin further increases QT prolongation and arrhythmia risk.
How serious is the interaction between Ibutilide and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibacterial while ibutilide is being used. Correct hypokalemia and hypomagnesemia and monitor ECG if exposure has occurred.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
