相互作用
Idarubicin + Trastuzumab deruxtecan
重症度: 重大
Idarubicin and Trastuzumab deruxtecan: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Trastuzumab-based therapy can cause cardiomyopathy and left ventricular dysfunction, and the risk is highest when given with anthracyclines. Idarubicin adds its own dose-related cardiotoxicity, and trastuzumab deruxtecan also carries risk of interstitial lung disease and myelosuppression.
この相互作用をわかりやすく説明すると
Idarubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idarubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
なぜ起こるのか
Additive cardiotoxicity from HER2 inhibition and anthracycline-induced myocardial injury.
対処法
Avoid concurrent use when possible and keep the interval between agents as long as practical. Check left ventricular ejection fraction before and during treatment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IdarubicinとTrastuzumab deruxtecanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Idarubicinのその他の相互作用
Trastuzumab deruxtecanのその他の相互作用
よくある質問
Can I take Idarubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Idarubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab-based therapy can cause cardiomyopathy and left ventricular dysfunction, and the risk is highest when given with anthracyclines. Idarubicin adds its own dose-related cardiotoxicity, and trastuzumab deruxtecan also carries risk of interstitial lung disease and myelosuppression.
How serious is the interaction between Idarubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible and keep the interval between agents as long as practical. Check left ventricular ejection fraction before and during treatment.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
