相互作用
Insulin degludec + Rosiglitazone
重症度: 重大
Insulin degludec and Rosiglitazone: major interaction.
最終更新日
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概要
Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
この相互作用をわかりやすく説明すると
Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Rosiglitazone belongs to Endocrine.
なぜ起こるのか
Additive glucose lowering from insulin sensitization plus exogenous insulin; fluid retention is also additive.
対処法
Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Insulin degludecとRosiglitazoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Insulin degludecのその他の相互作用
Rosiglitazoneのその他の相互作用
- Insulin aspart protamine / insulin aspart + Rosiglitazone 重大
- Insulin aspart-insulin aspart protamine + Rosiglitazone 重大
- Insulin aspart + Rosiglitazone 重大
- Insulin degludec / insulin aspart + Rosiglitazone 重大
- Insulin degludec-insulin aspart + Rosiglitazone 重大
- Insulin degludec-liraglutide + Rosiglitazone 重大
よくある質問
Can I take Insulin degludec with Rosiglitazone?
MediHelp rates the interaction as major. Insulin degludec and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity and enhances insulin's glucose-lowering effect, increasing hypoglycemia risk. Combination with insulin has also been associated with fluid retention, heart failure and possibly myocardial ischemia.
How serious is the interaction between Insulin degludec and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose as needed. Monitor for edema and heart failure signs, and avoid in patients with heart failure or high cardiovascular risk.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
