相互作用
Isocarboxazid + Ozanimod
重症度: 併用禁忌
Isocarboxazid and Ozanimod: contraindicated interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Ozanimod's active metabolites are formed and may inhibit MAO-B, and combining with a nonselective MAOI may raise the risk of hypertensive crisis or serotonin toxicity. Clinical interaction data are limited, but labeling advises against the combination.
この相互作用をわかりやすく説明すると
Isocarboxazid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
なぜ起こるのか
Additive MAO inhibition, with ozanimod metabolites contributing to MAO-B inhibition.
対処法
Do not co-administer; allow at least 14 days between stopping either agent and starting the other.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IsocarboxazidとOzanimodの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isocarboxazidのその他の相互作用
Ozanimodのその他の相互作用
よくある質問
Can I take Isocarboxazid with Ozanimod?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed and may inhibit MAO-B, and combining with a nonselective MAOI may raise the risk of hypertensive crisis or serotonin toxicity. Clinical interaction data are limited, but labeling advises against the combination.
How serious is the interaction between Isocarboxazid and Ozanimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days between stopping either agent and starting the other.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
