相互作用
Ketoconazole + Pralsetinib
重症度: 重大
Ketoconazole and Pralsetinib: major interaction.
最終更新日
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概要
Ketoconazole increases pralsetinib exposure and may intensify adverse effects such as hepatotoxicity, hypertension, hemorrhage, pneumonitis and myelosuppression.
この相互作用をわかりやすく説明すると
Ketoconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Pralsetinib belongs to Oncology.
なぜ起こるのか
Combined inhibition of CYP3A4 metabolism and P-glycoprotein efflux of pralsetinib.
対処法
Avoid the combination if possible; if required, reduce the pralsetinib dose per labeling and restore it after 3 to 5 half-lives of the inhibitor have elapsed post-discontinuation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、KetoconazoleとPralsetinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ketoconazoleのその他の相互作用
Pralsetinibのその他の相互作用
よくある質問
Can I take Ketoconazole with Pralsetinib?
MediHelp rates the interaction as major. Ketoconazole and Pralsetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole increases pralsetinib exposure and may intensify adverse effects such as hepatotoxicity, hypertension, hemorrhage, pneumonitis and myelosuppression.
How serious is the interaction between Ketoconazole and Pralsetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if required, reduce the pralsetinib dose per labeling and restore it after 3 to 5 half-lives of the inhibitor have elapsed post-discontinuation.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
