相互作用
Lenacapavir + Phenytoin
重症度: 併用禁忌
Lenacapavir and Phenytoin: contraindicated interaction.
最終更新日
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概要
Phenytoin is expected to considerably lower lenacapavir exposure, risking loss of virologic response and resistance.
この相互作用をわかりやすく説明すると
Lenacapavir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lenacapavir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
なぜ起こるのか
Phenytoin induces CYP3A4 and P-glycoprotein, which clear lenacapavir.
対処法
Do not co-administer; choose a non-inducing anticonvulsant.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LenacapavirとPhenytoinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Phenytoinのその他の相互作用
Lenacapavirのその他の相互作用
よくある質問
Can I take Lenacapavir with Phenytoin?
MediHelp rates the interaction as contraindicated. Lenacapavir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is expected to considerably lower lenacapavir exposure, risking loss of virologic response and resistance.
How serious is the interaction between Lenacapavir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose a non-inducing anticonvulsant.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
