相互作用
Micafungin + Midazolam intranasal
重症度: 軽度
Micafungin and Midazolam intranasal: minor interaction.
最終更新日
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概要
Midazolam is a sensitive CYP3A4 substrate, so even weak inhibitors can increase exposure and prolong sedation. Micafungin has little proven effect on CYP3A4 in practice, so any increase is likely small.
この相互作用をわかりやすく説明すると
Micafungin and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
なぜ起こるのか
Possible weak CYP3A4 inhibition by micafungin decreasing midazolam clearance.
対処法
Monitor sedation level and respiratory status after intranasal midazolam; no dose change is routinely needed.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MicafunginとMidazolam intranasalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Micafunginのその他の相互作用
よくある質問
Can I take Micafungin with Midazolam intranasal?
MediHelp rates the interaction as minor. Micafungin and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam is a sensitive CYP3A4 substrate, so even weak inhibitors can increase exposure and prolong sedation. Micafungin has little proven effect on CYP3A4 in practice, so any increase is likely small.
How serious is the interaction between Micafungin and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after intranasal midazolam; no dose change is routinely needed.
What other medicines interact with Micafungin?
MediHelp also lists interactions of Micafungin with, for example, Lomitapide, Saccharomyces boulardii, Sirolimus. The full list is on the Micafungin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
