相互作用
Miconazole + Simvastatin
重症度: 重大
Miconazole and Simvastatin: major interaction.
最終更新日
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概要
Systemic miconazole can increase simvastatin exposure and the risk of myopathy and rhabdomyolysis. Vaginal absorption is limited, but caution is warranted given the narrow safety margin.
この相互作用をわかりやすく説明すると
Miconazole and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Miconazole belongs to Anti Fungals; Simvastatin belongs to Cardiovascular.
なぜ起こるのか
Miconazole inhibits CYP3A4 metabolism of simvastatin.
対処法
Avoid with oral or buccal miconazole; withhold simvastatin during therapy. With vaginal use, monitor for muscle symptoms or use a non-CYP3A4 statin temporarily.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MiconazoleとSimvastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Miconazoleのその他の相互作用
Simvastatinのその他の相互作用
よくある質問
Can I take Miconazole with Simvastatin?
MediHelp rates the interaction as major. Miconazole and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic miconazole can increase simvastatin exposure and the risk of myopathy and rhabdomyolysis. Vaginal absorption is limited, but caution is warranted given the narrow safety margin.
How serious is the interaction between Miconazole and Simvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral or buccal miconazole; withhold simvastatin during therapy. With vaginal use, monitor for muscle symptoms or use a non-CYP3A4 statin temporarily.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
