相互作用
Dihydroergotamine + Nitroglycerin
重症度: 重大
Dihydroergotamine and Nitroglycerin: major interaction.
最終更新日
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概要
Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability by reducing its first-pass metabolism, increasing vasospasm risk. Angina patients are particularly at risk.
この相互作用をわかりやすく説明すると
Dihydroergotamine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Nitroglycerin belongs to Cardiovascular.
なぜ起こるのか
Opposing vasoactive effects, with possible increased dihydroergotamine exposure caused by nitrates.
対処法
Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、DihydroergotamineとNitroglycerinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Nitroglycerinのその他の相互作用
Dihydroergotamineのその他の相互作用
よくある質問
Can I take Dihydroergotamine with Nitroglycerin?
MediHelp rates the interaction as major. Dihydroergotamine and Nitroglycerin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine causes vasoconstriction that opposes nitroglycerin's vasodilation and may worsen myocardial ischemia. Nitrates may also raise ergot bioavailability by reducing its first-pass metabolism, increasing vasospasm risk. Angina patients are particularly at risk.
How serious is the interaction between Dihydroergotamine and Nitroglycerin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dihydroergotamine in patients needing nitrates for coronary disease and use an alternative migraine therapy. If both are given, monitor for chest pain and ischemic symptoms.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
