相互作用
Ondansetron + Thioridazine
重症度: 併用禁忌
Ondansetron and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine causes marked dose-related QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding ondansetron further increases the risk of torsades de pointes and sudden cardiac death.
この相互作用をわかりやすく説明すると
Ondansetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ondansetron belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation through blockade of cardiac potassium channels.
対処法
Avoid the combination and choose an antiemetic with less QT effect, such as one without 5-HT3 antagonism, with ECG review. If unavoidable, correct electrolytes and monitor the ECG continuously.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、OndansetronとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ondansetronのその他の相互作用
Thioridazineのその他の相互作用
よくある質問
Can I take Ondansetron with Thioridazine?
MediHelp rates the interaction as contraindicated. Ondansetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked dose-related QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding ondansetron further increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Ondansetron and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiemetic with less QT effect, such as one without 5-HT3 antagonism, with ECG review. If unavoidable, correct electrolytes and monitor the ECG continuously.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Vandetanib, Adagrasib. The full list is on the Ondansetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
