相互作用
Amiodarone + Ondansetron
重症度: 重大
Amiodarone and Ondansetron: major interaction.
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Both drugs prolong the QT interval and the combination increases the risk of torsades de pointes. Risk is greatest with intravenous ondansetron at higher doses and in patients with electrolyte disturbance, bradycardia, heart disease or female sex. Amiodarone's long half-life means the risk persists after discontinuation.
この相互作用をわかりやすく説明すると
Amiodarone and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Ondansetron belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive blockade of the hERG potassium channel (IKr) causing delayed ventricular repolarisation.
対処法
Prefer a non-QT-prolonging antiemetic where possible. If ondansetron is needed, use the lowest dose, obtain a baseline ECG and correct potassium and magnesium.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとOndansetronの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
参考文献
Ondansetronのその他の相互作用
Amiodaroneのその他の相互作用
よくある質問
Can I take Amiodarone with Ondansetron?
MediHelp rates the interaction as major. Amiodarone and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval and the combination increases the risk of torsades de pointes. Risk is greatest with intravenous ondansetron at higher doses and in patients with electrolyte disturbance, bradycardia, heart disease or female sex. Amiodarone's long half-life means the risk persists after discontinuation.
How serious is the interaction between Amiodarone and Ondansetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antiemetic where possible. If ondansetron is needed, use the lowest dose, obtain a baseline ECG and correct potassium and magnesium.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
