相互作用
Amisulpride + Ondansetron
重症度: 重大
Amisulpride and Ondansetron: major interaction.
最終更新日
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概要
Both drugs prolong the QT interval, and intravenous amisulpride for nausea carries a labeled warning about other QT-prolonging drugs. Together they raise the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Amisulpride and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive prolongation of cardiac repolarization.
対処法
Avoid or use another antiemetic where feasible. If given together, correct electrolytes and monitor the ECG.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとOndansetronの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ondansetronのその他の相互作用
Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Ondansetron?
MediHelp rates the interaction as major. Amisulpride and Ondansetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and intravenous amisulpride for nausea carries a labeled warning about other QT-prolonging drugs. Together they raise the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Ondansetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or use another antiemetic where feasible. If given together, correct electrolytes and monitor the ECG.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
