相互作用
Oxybutynin + Potassium chloride
重症度: 重大
Oxybutynin and Potassium chloride: major interaction.
最終更新日
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概要
Anticholinergic drugs slow gastrointestinal transit, so solid potassium chloride tablets stay in contact with the mucosa for longer. This raises the risk of local ulceration, bleeding, stricture or perforation.
この相互作用をわかりやすく説明すると
Oxybutynin and Potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxybutynin belongs to Genitourinary; Potassium chloride belongs to Gastrointestinal Tract.
なぜ起こるのか
Reduced GI motility from anticholinergic action prolongs mucosal exposure to the high local potassium concentration released by solid dosage forms.
対処法
Use a liquid or effervescent potassium formulation instead of solid oral tablets in patients taking oxybutynin. Report any abdominal pain, vomiting or GI bleeding promptly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、OxybutyninとPotassium chlorideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Oxybutyninのその他の相互作用
Potassium chlorideのその他の相互作用
よくある質問
Can I take Oxybutynin with Potassium chloride?
MediHelp rates the interaction as major. Oxybutynin and Potassium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anticholinergic drugs slow gastrointestinal transit, so solid potassium chloride tablets stay in contact with the mucosa for longer. This raises the risk of local ulceration, bleeding, stricture or perforation.
How serious is the interaction between Oxybutynin and Potassium chloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a liquid or effervescent potassium formulation instead of solid oral tablets in patients taking oxybutynin. Report any abdominal pain, vomiting or GI bleeding promptly.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Rivastigmine. The full list is on the Oxybutynin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
