相互作用
Riociguat + Tadalafil
重症度: 併用禁忌
Riociguat and Tadalafil: contraindicated interaction.
最終更新日
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概要
Riociguat combined with a PDE5 inhibitor such as tadalafil produces additive systemic vasodilation and symptomatic hypotension. In a pulmonary hypertension trial this combination showed no favorable benefit and raised safety concerns, and labeling prohibits it.
この相互作用をわかりやすく説明すると
Riociguat and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
なぜ起こるのか
Riociguat stimulates soluble guanylate cyclase to produce cGMP while tadalafil prevents its breakdown, causing additive vasodilation.
対処法
Do not coadminister; choose one agent. When switching, follow labeled washout intervals between the drugs.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、RiociguatとTadalafilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tadalafilのその他の相互作用
Riociguatのその他の相互作用
よくある質問
Can I take Riociguat with Tadalafil?
MediHelp rates the interaction as contraindicated. Riociguat and Tadalafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat combined with a PDE5 inhibitor such as tadalafil produces additive systemic vasodilation and symptomatic hypotension. In a pulmonary hypertension trial this combination showed no favorable benefit and raised safety concerns, and labeling prohibits it.
How serious is the interaction between Riociguat and Tadalafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose one agent. When switching, follow labeled washout intervals between the drugs.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
