相互作用
Riociguat + Sildenafil
重症度: 併用禁忌
Riociguat and Sildenafil: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.
この相互作用をわかりやすく説明すると
Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
なぜ起こるのか
Riociguat stimulates soluble guanylate cyclase to raise cGMP, and sildenafil blocks cGMP degradation via PDE5, so the effects on the nitric oxide-cGMP pathway are additive.
対処法
Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、RiociguatとSildenafilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Adempas (riociguat) Prescribing Information - Contraindications — FDA Label
- Adempas (riociguat) Summary of Product Characteristics — EMA SmPC
Riociguatのその他の相互作用
Sildenafilのその他の相互作用
よくある質問
Can I take Riociguat with Sildenafil?
MediHelp rates the interaction as contraindicated. Riociguat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining riociguat with PDE5 inhibitors such as sildenafil causes additive systemic vasodilation and can lead to hypotension. In a pulmonary arterial hypertension study, adding riociguat to sildenafil showed no favorable benefit and was associated with unfavorable outcomes including more deaths. Riociguat labeling contraindicates concomitant PDE5 inhibitors.
How serious is the interaction between Riociguat and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two together. When switching, stop sildenafil at least 24 hours before starting riociguat, and consider specialist guidance on the transition.
What other medicines interact with Riociguat?
MediHelp also lists interactions of Riociguat with, for example, Avanafil, Dipyridamole, Isosorbide dinitrate. The full list is on the Riociguat page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
