相互作用
Tretinoin + Urea
重症度: 軽度
Tretinoin and Urea: minor interaction.
最終更新日 出典: US FDA label
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概要
Concurrent topical use may increase irritation, dryness and peeling at the application site. Urea may increase skin penetration of tretinoin through its effects on the stratum corneum. The effect is usually mild and local, but sensitive or compromised skin is at greater risk.
この相互作用をわかりやすく説明すると
Tretinoin and Urea have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tretinoin belongs to Dermatology; Urea belongs to Miscellaneous.
なぜ起こるのか
Additive local irritation from the retinoid and keratolytic urea, with possible increased tretinoin penetration through a disrupted stratum corneum.
対処法
Apply at separate times, for example urea in the morning and tretinoin at night, and avoid high-strength urea on the same area at first. Start with low frequency and monitor for irritation.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、TretinoinとUreaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
- Retin-A (tretinoin) Prescribing Information — FDA Label
Tretinoinのその他の相互作用
Ureaのその他の相互作用
よくある質問
Can I take Tretinoin with Urea?
MediHelp rates the interaction as minor. Tretinoin and Urea have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent topical use may increase irritation, dryness and peeling at the application site. Urea may increase skin penetration of tretinoin through its effects on the stratum corneum. The effect is usually mild and local, but sensitive or compromised skin is at greater risk.
How serious is the interaction between Tretinoin and Urea?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Apply at separate times, for example urea in the morning and tretinoin at night, and avoid high-strength urea on the same area at first. Start with low frequency and monitor for irritation.
What other medicines interact with Tretinoin?
MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
