Referência de medicamentos
Riociguat
Riociguat is a medicine in the class cardiovascular. It is used for pulmonary hypertension.
- Classe do medicamento: Cardiovascular
- Indicado para: pulmonary hypertension
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Pontos-chave
- Classe do medicamento
- Cardiovascular
- Código ATC
- C02KX05
- Formas farmacêuticas comuns
- comprimido
- Concentrações comuns
- 0.5 mg
- Interações conhecidas
- 79 (Contraindicada: 9 · Grave: 9 · Moderada: 49 · Leve: 12)
- Nomes comerciais
- 3
- Países e mercados
- 3
Para que é usado
Como funciona
Stimulator of soluble guanylate cyclase (sGC). It sensitizes sGC to endogenous nitric oxide and also directly stimulates sGC independently of NO, increasing cGMP and causing vasodilation.
Dose habitual em adultos (resumo da bula)
CTEPH or PAH: start 1 mg orally three times a day (consider 0.5 mg three times a day if hypotension may not be tolerated); if systolic BP stays above 95 mmHg with no hypotension symptoms, increase by 0.5 mg three times a day no sooner than every 2 weeks; maximum 2.5 mg three times a day
Gravidez e amamentação
- Gravidez
- Unsafe Contraindicated in pregnancy; animal studies show fetal harm including birth defects, fetal death and miscarriage. Human data are limited.
- Amamentação
- Unsafe No human milk data; present in rat milk. Advise not to breastfeed because of risk of hypotension in infants.
Efeitos adversos relatados
- Headache
- Dyspepsia and gastritis
- Dizziness
- Nausea
- Diarrhea
- Hypotension
Advertências de caixa preta
- Embryo-fetal toxicity: contraindicated in pregnancy because it may cause fetal harm based on animal data. Exclude pregnancy before treatment. Use effective contraception before, during and for one month after treatment. If pregnancy is detected, discontinue as soon as possible.
Contraindicações
- Pregnancy
- Concomitant nitrates or nitric oxide donors in any form
- Concomitant PDE inhibitors (specific PDE-5 inhibitors and nonspecific such as dipyridamole or theophylline)
Quem deve ter cuidado
- Hypotension: reduces blood pressure; consider risk in hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, antihypertensives or strong CYP/P-gp/BCRP inhibitors; consider dose reduction.
- Bleeding: serious bleeding occurred in 2.4% of patients on Adempas vs 0% placebo, including serious hemoptysis in 1%.
- Pulmonary veno-occlusive disease: not recommended; if pulmonary edema occurs, consider PVOD and discontinue if confirmed.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (79)
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
- Riociguat + Tadalafil Contraindicated
- Riociguat + Theophylline Contraindicated
- Riociguat + Vardenafil Contraindicated
- Apalutamide + Riociguat Major
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- Renal and hepatic dose adjustments
- Dosing in older adults
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- Patient counselling points
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Perguntas frequentes
What is Riociguat used for?
Riociguat is a medicine in the class cardiovascular. It is used for Pulmonary hypertension.
What side effects have been reported with Riociguat?
Headache, Dyspepsia and gastritis, Dizziness, Nausea, Diarrhea, Hypotension. Serious warning: Embryo-fetal toxicity: contraindicated in pregnancy because it may cause fetal harm based on animal data.
Can Riociguat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy; animal studies show fetal harm including birth defects, fetal death and miscarriage. Human data are limited. Breastfeeding: Unsafe. No human milk data; present in rat milk. Advise not to breastfeed because of risk of hypotension in infants.
What does Riociguat interact with?
MediHelp lists 79 known interactions for Riociguat. Contraindicated: 9 · Major: 9 · Moderate: 49 · Minor: 12. The most serious include Avanafil, Dipyridamole, Isosorbide dinitrate.
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