Interações medicamentosas
Nitroglycerin + Riociguat
Gravidade: Contraindicada
Nitroglycerin and Riociguat: contraindicated interaction.
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Resumo
Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
O que esta interação significa em palavras simples
Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nitroglycerin belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Por que acontece
Additive cGMP-mediated vasodilation from nitric oxide donation and soluble guanylate cyclase stimulation.
O que fazer
Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Nitroglycerin
- Avanafil + Nitroglycerin Contraindicada
- Nitroglycerin + Sildenafil Contraindicada
- Nitroglycerin + Tadalafil Contraindicada
- Nitroglycerin + Vardenafil Contraindicada
- Dihydroergotamine intranasal + Nitroglycerin Grave
- Dihydroergotamine + Nitroglycerin Grave
Outras interações de Riociguat
- Avanafil + Riociguat Contraindicada
- Dipyridamole + Riociguat Contraindicada
- Isosorbide dinitrate + Riociguat Contraindicada
- Isosorbide mononitrate + Riociguat Contraindicada
- Riociguat + Sildenafil Contraindicada
- Riociguat + Tadalafil Contraindicada
Perguntas frequentes
Can I take Nitroglycerin with Riociguat?
MediHelp rates the interaction as contraindicated. Nitroglycerin and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
How serious is the interaction between Nitroglycerin and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-nitrate option for angina or acute needs while on riociguat.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Nitroglycerin page.
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