Interações medicamentosas
Isosorbide dinitrate + Riociguat
Gravidade: Contraindicada
Isosorbide dinitrate and Riociguat: contraindicated interaction.
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Resumo
Both drugs increase cyclic GMP signalling in vascular smooth muscle, and together they can cause profound, sometimes refractory hypotension and syncope. Riociguat labeling contraindicates its use with nitrates in any form.
O que esta interação significa em palavras simples
Isosorbide dinitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide dinitrate belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Por que acontece
Nitrates release nitric oxide while riociguat stimulates soluble guanylate cyclase, producing additive cGMP-mediated vasodilation.
O que fazer
Do not co-administer riociguat with isosorbide dinitrate or other nitrates. Choose a non-nitrate antianginal if one is needed.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicada
- Isosorbide dinitrate + Sildenafil Contraindicada
- Isosorbide dinitrate + Tadalafil Contraindicada
- Isosorbide dinitrate + Vardenafil Contraindicada
- Ergotamine + Isosorbide dinitrate Grave
- Isosorbide dinitrate + Methylergonovine Grave
Outras interações de Riociguat
- Avanafil + Riociguat Contraindicada
- Dipyridamole + Riociguat Contraindicada
- Isosorbide mononitrate + Riociguat Contraindicada
- Nitroglycerin + Riociguat Contraindicada
- Riociguat + Sildenafil Contraindicada
- Riociguat + Tadalafil Contraindicada
Perguntas frequentes
Can I take Isosorbide dinitrate with Riociguat?
MediHelp rates the interaction as contraindicated. Isosorbide dinitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs increase cyclic GMP signalling in vascular smooth muscle, and together they can cause profound, sometimes refractory hypotension and syncope. Riociguat labeling contraindicates its use with nitrates in any form.
How serious is the interaction between Isosorbide dinitrate and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer riociguat with isosorbide dinitrate or other nitrates. Choose a non-nitrate antianginal if one is needed.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Isosorbide dinitrate page.
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