Interações medicamentosas
Isosorbide mononitrate + Riociguat
Gravidade: Contraindicada
Isosorbide mononitrate and Riociguat: contraindicated interaction.
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Resumo
Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
O que esta interação significa em palavras simples
Isosorbide mononitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isosorbide mononitrate belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Por que acontece
Additive cGMP-mediated vasodilation from nitric oxide donation and soluble guanylate cyclase stimulation.
O que fazer
Do not co-administer. Use a non-nitrate antianginal while on riociguat.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isosorbide mononitrate
- Avanafil + Isosorbide mononitrate Contraindicada
- Isosorbide mononitrate + Sildenafil Contraindicada
- Isosorbide mononitrate + Tadalafil Contraindicada
- Isosorbide mononitrate + Vardenafil Contraindicada
- Ergotamine + Isosorbide mononitrate Grave
- Isosorbide mononitrate + Methylergonovine Grave
Outras interações de Riociguat
- Avanafil + Riociguat Contraindicada
- Dipyridamole + Riociguat Contraindicada
- Isosorbide dinitrate + Riociguat Contraindicada
- Nitroglycerin + Riociguat Contraindicada
- Riociguat + Sildenafil Contraindicada
- Riociguat + Tadalafil Contraindicada
Perguntas frequentes
Can I take Isosorbide mononitrate with Riociguat?
MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Riociguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat stimulates soluble guanylate cyclase and nitrates supply nitric oxide, producing additive vasodilation. Severe, potentially life-threatening hypotension can result. Labeling contraindicates concomitant use of riociguat with nitrates in any form.
How serious is the interaction between Isosorbide mononitrate and Riociguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-nitrate antianginal while on riociguat.
What other medicines interact with Isosorbide mononitrate?
MediHelp also lists interactions of Isosorbide mononitrate with, for example, Avanafil, Sildenafil, Tadalafil. The full list is on the Isosorbide mononitrate page.
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