Referência de medicamentos
Venetoclax
Venetoclax is a medicine in the class miscellaneous. It is used for chronic lymphocytic leukemia.
- Classe do medicamento: Miscellaneous
- Indicado para: chronic lymphocytic leukemia
Última atualização Fontes: US FDA label
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Pontos-chave
- Classe do medicamento
- Miscellaneous
- Código ATC
- L01XX52
- Formas farmacêuticas comuns
- comprimido
- Concentrações comuns
- 10 mg
- Interações conhecidas
- 68 (Contraindicada: 5 · Grave: 37 · Moderada: 23 · Leve: 3)
- Nomes comerciais
- 3
- Países e mercados
- 3
Para que é usado
Como funciona
Selective, orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein. It binds BCL-2 directly, displacing pro-apoptotic proteins like BIM, which restores apoptosis through mitochondrial outer membrane permeabilization and caspase activation.
Dose habitual em adultos (resumo da bula)
CLL/SLL: 5-week ramp-up orally once daily (Week 1 20 mg, Week 2 50 mg, Week 3 100 mg, Week 4 200 mg), then 400 mg once daily from Week 5 and beyond
Gravidez e amamentação
- Gravidez
- Unsafe May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose.
- Amamentação
- Unsafe No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
Efeitos adversos relatados
- Neutropenia
- Thrombocytopenia
- Anemia
- Diarrhea
- Nausea
- Fatigue
Contraindicações
- Concomitant use with strong CYP3A inhibitors at initiation and during the ramp-up phase in patients with CLL/SLL, due to increased TLS risk
Quem deve ter cuidado
- Tumor lysis syndrome, including fatal events and renal failure requiring dialysis; assess risk, give hydration and anti-hyperuricemics, and monitor blood chemistries
- Neutropenia: monitor complete blood counts throughout treatment and consider supportive measures
- Fatal and serious infections such as pneumonia and sepsis; withhold for Grade 3 and 4 infection until resolution
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (68)
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
- Apalutamide + Venetoclax Major
- Aprepitant + Venetoclax Major
- Armodafinil + Venetoclax Major
- Bosentan + Venetoclax Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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- Pharmacokinetics
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Perguntas frequentes
What is Venetoclax used for?
Venetoclax is a medicine in the class miscellaneous. It is used for Chronic lymphocytic leukemia, Leukemia.
What side effects have been reported with Venetoclax?
Neutropenia, Thrombocytopenia, Anemia, Diarrhea, Nausea, Fatigue.
Can Venetoclax be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose. Breastfeeding: Unsafe. No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
What does Venetoclax interact with?
MediHelp lists 68 known interactions for Venetoclax. Contraindicated: 5 · Major: 37 · Moderate: 23 · Minor: 3. The most serious include Clarithromycin, Itraconazole, Ketoconazole.
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