Interações medicamentosas
Clarithromycin + Venetoclax
Gravidade: Contraindicada
Clarithromycin and Venetoclax: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Clarithromycin increases venetoclax exposure through CYP3A4 and P-glycoprotein inhibition. During initiation and dose ramp-up this increases the risk of tumor lysis syndrome and neutropenia. After ramp-up, strong inhibitors require a major venetoclax dose reduction.
O que esta interação significa em palavras simples
Clarithromycin and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Venetoclax belongs to Miscellaneous.
Por que acontece
Inhibition of CYP3A4 and P-glycoprotein reduces venetoclax clearance and increases absorption.
O que fazer
Do not use during venetoclax initiation or ramp-up; use an alternative antibiotic. After ramp-up, if unavoidable, reduce the venetoclax dose by at least 75% and monitor for toxicity and blood counts.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Clarithromycin e Venetoclax, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Venetoclax
- Itraconazole + Venetoclax Contraindicada
- Ketoconazole + Venetoclax Contraindicada
- Posaconazole + Venetoclax Contraindicada
- Venetoclax + Voriconazole Contraindicada
- Amiodarone + Venetoclax Grave
- Apalutamide + Venetoclax Grave
Perguntas frequentes
Can I take Clarithromycin with Venetoclax?
MediHelp rates the interaction as contraindicated. Clarithromycin and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin increases venetoclax exposure through CYP3A4 and P-glycoprotein inhibition. During initiation and dose ramp-up this increases the risk of tumor lysis syndrome and neutropenia. After ramp-up, strong inhibitors require a major venetoclax dose reduction.
How serious is the interaction between Clarithromycin and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during venetoclax initiation or ramp-up; use an alternative antibiotic. After ramp-up, if unavoidable, reduce the venetoclax dose by at least 75% and monitor for toxicity and blood counts.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
