Interações medicamentosas
Ketoconazole + Venetoclax
Gravidade: Contraindicada
Ketoconazole and Venetoclax: contraindicated interaction.
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Resumo
Ketoconazole markedly raises venetoclax exposure, increasing the risk of tumor lysis syndrome and neutropenia. It is contraindicated during the initial ramp-up phase.
O que esta interação significa em palavras simples
Ketoconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
Por que acontece
Strong CYP3A4 inhibition (and P-gp inhibition) reduces venetoclax clearance.
O que fazer
Avoid during ramp-up. After ramp-up, reduce the venetoclax dose by at least 75% and monitor for toxicity.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ketoconazole
- Alfuzosin + Ketoconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Avanafil + Ketoconazole Contraindicada
- Conivaptan + Ketoconazole Contraindicada
- Dihydroergotamine intranasal + Ketoconazole Contraindicada
- Dihydroergotamine + Ketoconazole Contraindicada
Outras interações de Venetoclax
- Clarithromycin + Venetoclax Contraindicada
- Itraconazole + Venetoclax Contraindicada
- Posaconazole + Venetoclax Contraindicada
- Venetoclax + Voriconazole Contraindicada
- Amiodarone + Venetoclax Grave
- Apalutamide + Venetoclax Grave
Perguntas frequentes
Can I take Ketoconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Ketoconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly raises venetoclax exposure, increasing the risk of tumor lysis syndrome and neutropenia. It is contraindicated during the initial ramp-up phase.
How serious is the interaction between Ketoconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during ramp-up. After ramp-up, reduce the venetoclax dose by at least 75% and monitor for toxicity.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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