Interações medicamentosas
Posaconazole + Venetoclax
Gravidade: Contraindicada
Posaconazole and Venetoclax: contraindicated interaction.
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Resumo
Posaconazole significantly increases venetoclax exposure, raising the risk of tumor lysis syndrome during ramp-up and of neutropenia and other toxicity afterward.
O que esta interação significa em palavras simples
Posaconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Posaconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
Por que acontece
Posaconazole strongly inhibits CYP3A4 and may inhibit P-glycoprotein, reducing venetoclax clearance.
O que fazer
Do not use during venetoclax initiation and ramp-up. After ramp-up, reduce the venetoclax dose per labeling (substantially) and monitor for toxicity and blood counts.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Posaconazole
- Artemether + Posaconazole Contraindicada
- Avanafil + Posaconazole Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Conivaptan + Posaconazole Contraindicada
- Dihydroergotamine intranasal + Posaconazole Contraindicada
- Dihydroergotamine + Posaconazole Contraindicada
Outras interações de Venetoclax
- Clarithromycin + Venetoclax Contraindicada
- Itraconazole + Venetoclax Contraindicada
- Ketoconazole + Venetoclax Contraindicada
- Venetoclax + Voriconazole Contraindicada
- Amiodarone + Venetoclax Grave
- Apalutamide + Venetoclax Grave
Perguntas frequentes
Can I take Posaconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Posaconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole significantly increases venetoclax exposure, raising the risk of tumor lysis syndrome during ramp-up and of neutropenia and other toxicity afterward.
How serious is the interaction between Posaconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during venetoclax initiation and ramp-up. After ramp-up, reduce the venetoclax dose per labeling (substantially) and monitor for toxicity and blood counts.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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