Interações medicamentosas
Amiodarone + Venetoclax
Gravidade: Grave
Amiodarone and Venetoclax: major interaction.
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Resumo
Amiodarone may increase venetoclax exposure, raising the risk of neutropenia and, in patients with high tumor burden, tumor lysis syndrome. Both CYP3A and P-gp inhibition contribute to this effect.
O que esta interação significa em palavras simples
Amiodarone and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Por que acontece
Amiodarone inhibits CYP3A4 and P-gp, decreasing venetoclax metabolism and efflux.
O que fazer
Avoid if possible; otherwise reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the prior dose after the inhibitor has been cleared, noting the long amiodarone half-life.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Outras interações de Venetoclax
- Clarithromycin + Venetoclax Contraindicada
- Itraconazole + Venetoclax Contraindicada
- Ketoconazole + Venetoclax Contraindicada
- Posaconazole + Venetoclax Contraindicada
- Venetoclax + Voriconazole Contraindicada
- Apalutamide + Venetoclax Grave
Perguntas frequentes
Can I take Amiodarone with Venetoclax?
MediHelp rates the interaction as major. Amiodarone and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may increase venetoclax exposure, raising the risk of neutropenia and, in patients with high tumor burden, tumor lysis syndrome. Both CYP3A and P-gp inhibition contribute to this effect.
How serious is the interaction between Amiodarone and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the venetoclax dose by at least 50% and monitor blood counts and for tumor lysis. Resume the prior dose after the inhibitor has been cleared, noting the long amiodarone half-life.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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