Interações medicamentosas
Allopurinol + Ampicillin-sulbactam
Gravidade: Moderada
Allopurinol and Ampicillin-sulbactam: moderate interaction.
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Resumo
Patients taking allopurinol and ampicillin have shown a higher rate of skin rash than with either drug alone. Rash is usually mild but can obscure or be mistaken for a serious hypersensitivity reaction.
O que esta interação significa em palavras simples
Allopurinol and Ampicillin-sulbactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Ampicillin-sulbactam belongs to Anti Bacterial.
Por que acontece
Mechanism unknown; possibly additive hypersensitivity or an effect of hyperuricemia on rash.
O que fazer
Counsel patients to report any rash promptly and stop the drugs if rash is severe or accompanied by fever, mucosal lesions or blistering; consider an alternative antibiotic if feasible.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Ampicillin-sulbactam
Outras interações de Allopurinol
Perguntas frequentes
Can I take Allopurinol with Ampicillin-sulbactam?
MediHelp rates the interaction as moderate. Allopurinol and Ampicillin-sulbactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients taking allopurinol and ampicillin have shown a higher rate of skin rash than with either drug alone. Rash is usually mild but can obscure or be mistaken for a serious hypersensitivity reaction.
How serious is the interaction between Allopurinol and Ampicillin-sulbactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report any rash promptly and stop the drugs if rash is severe or accompanied by fever, mucosal lesions or blistering; consider an alternative antibiotic if feasible.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin-sulbactam page.
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