Pular para o conteúdo

Interações medicamentosas

Alprazolam + Sufentanil

Gravidade: Grave

Alprazolam and Sufentanil: major interaction.

Última atualização Fontes: US FDA label

Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Combining a benzodiazepine with a potent opioid like sufentanil can cause profound sedation, respiratory depression, coma and death. Regulators warn specifically about this class combination.

O que esta interação significa em palavras simples

Alprazolam and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Alprazolam belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.

Nível de evidência: High

Por que acontece

Additive CNS and respiratory depression from opioid receptor agonism and GABA-A modulation.

O que fazer

Reserve for situations without alternatives, using the lowest doses and monitoring continuously for respiratory depression and sedation. Ensure resuscitation equipment and naloxone are available.

O que perguntar ao farmacêutico

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Para assinantes do Pro+

Desbloqueie a página completa

Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Alprazolam e Sufentanil, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Experimente o Pro+ grátis por 7 dias na web. Sem cartão.

Referências

Perguntas frequentes

Can I take Alprazolam with Sufentanil?

MediHelp rates the interaction as major. Alprazolam and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with a potent opioid like sufentanil can cause profound sedation, respiratory depression, coma and death. Regulators warn specifically about this class combination.

How serious is the interaction between Alprazolam and Sufentanil?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for situations without alternatives, using the lowest doses and monitoring continuously for respiratory depression and sedation. Ensure resuscitation equipment and naloxone are available.

What other medicines interact with Alprazolam?

MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.

Monografias completas, posologia e verificador de interações no app MediHelp

Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.

Explorar de A a Z · Interações medicamentosas

Baixar o app Entrar