Interações medicamentosas
Baclofen + Sufentanil
Gravidade: Grave
Baclofen and Sufentanil: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Baclofen and opioids both depress the central nervous system, and sufentanil is a very potent opioid. Together they can cause profound sedation, hypotension and respiratory depression, and intrathecal baclofen adds particular risk in the perioperative setting.
O que esta interação significa em palavras simples
Baclofen and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baclofen belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression from opioid mu-receptor agonism and baclofen GABA-B agonism.
O que fazer
Use reduced opioid doses and monitor respiratory rate, oxygen saturation and level of consciousness, with naloxone available. Continuous monitoring is advisable after sufentanil administration.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
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Outras interações de Baclofen
Outras interações de Sufentanil
Perguntas frequentes
Can I take Baclofen with Sufentanil?
MediHelp rates the interaction as major. Baclofen and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baclofen and opioids both depress the central nervous system, and sufentanil is a very potent opioid. Together they can cause profound sedation, hypotension and respiratory depression, and intrathecal baclofen adds particular risk in the perioperative setting.
How serious is the interaction between Baclofen and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced opioid doses and monitor respiratory rate, oxygen saturation and level of consciousness, with naloxone available. Continuous monitoring is advisable after sufentanil administration.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
